Which approach should be implemented to address concerns related to the use of multiple anticholinergic agents?

1. Regular medication reviews for anticholinergic burden, particularly during transitions of care
2. Engage in shared-decision making when deprescribing inappropriate anticholinergic medications
3. Consider safer alternatives and non-pharmacologic options
4. All of the above

Correct answer - D. All of the above

Management of anticholinergic polypharmacy requires comprehensive medication review with patient-centered shared decision-making. Since patients often perceive anticholinergic medications as beneficial, successful deprescribing requires clear risk versus benefit communication and patient agreement with their treatment plan. Please see the article titled Use of Multiple Anticholinergic Agents in Older Adults for more information.